HOME    »    PROGRAMS/ACTIVITIES    »    Annual Thematic Program
Immune System Modeling and Cell Signaling
October 12-16, 1998



Organizers:

Byron Goldstein
Los Alamos National Laboratory


Denise Kirschner
University of Michigan


Alan Perelson
Los Alamos National Laboratory

and

Lee Segel
Weizmann Institute of Science


The general goal of this workshop is to bring together immune system theorists and experimental immunologists with mathematicians who can become stimulated in this exciting and important area, and who may be able to make an impact by contributing new methods and tools of analysis. At the moment there are a small number of intense collaborations between mathematical modelers and experimental immunologists. A goal of this workshop is to stimulate more collaborations of this type. Prior to the start of the workshop tutorials will be given on cell signaling, the physiology of the immune system, and the dynamics of the immune response in order to provide the mathematicians with sufficient background to effectively participate in the workshop.

First we will consider how cells of the immune system receive and send signals, i.e., how their surface receptors initiate signalling cascades, and how these cells secrete lymphokines that stimulate other cells of the immune system. We will then focus on questions concerning the dynamics of interactions among B cells, T cells, and antigen presenting cells, and the regulation of these populations. We will examine events occuring during immune responses, including the formation of spatial structures, such as germinal centers, as well as problems dealing with somatic mutation and affinity maturation. The mathematics employed will involve systems of nonlinear ordinary differential equations, partial differential equations, cellular automata, stochastic processes, and computer simulation.



WORKSHOP SCHEDULE

All talks are in Lecture Hall EE/CS 3-180 unless otherwise noted.

Monday Tuesday Wednesday Thursday Friday

MONDAY, OCTOBER 12
8:45 am Registration and Coffee Reception Room EE/CS 3-176
9:15 am Willard Miller, Jr., Fred Dulles, and Alan S. Perelson Introduction and Overview
9:30 am Alan S. Perelson,
Theoretical Biology & Biophysics
Modeling Primary Immune Responses
10:30 am Coffee Break EE/CS 3-176
11:00 am Marc Jenkins,
Dept. of Immunology and Microbiology
University of Minnesota
Tracking the Interactions Between Antigen-Specific T and B Cells in situ
2:00 pm Byron Goldstein,
Los Alamos National Laboratories
Aggregating Receptor Systems
2:30 pm Henry Metzger (NIH) Signal transduction by the FceRI: Analysis of the early molecular events
4:00 pm IMA Tea Lind Hall 400
TUESDAY, OCTOBER 13
9:15 am Coffee Break EE/CS 3-176
9:30 am John Cambier,
National Jewish Medical and Research Center
Antigen Receptors, Their Accessories and Signal Transduction in B Lymphocytes
10:30 am Coffee Break EE/CS 3-176
11:00 pm Carla Wofsy,
University of New Mexico
A Little Lyn Goes a Long Way: Results of an Experimental/Theoretical Collaboration
2:00 pm Philip E. Seiden
IBM/Princeton
ImmSim: A Cellular Automaton Model for Simulation of the Immune System
2:30 pm Derek Smith
University of New Mexico
Simulating Immune Responses
3:00 pm Coffee Break EE/CS 3-176
3:15 pm Ramit Mehr
Princeton University
Meta-Dynamics of Lymphocyte Repertoire Development
WEDNESDAY, OCTOBER 14
9:15 am Coffee Break EE/CS 3-176
9:30 am Barbara Baird
Cornell University
Membrane Organization in IgE-Receptor Signaling
10:30 am Coffee Break EE/CS 3-176
11:00 am Jason Haugh
Massachusetts Institute of Technology
Spatial Effects in Receptor-mediated Signal Transduction
2:00 pm Rustom Antia
Emory University
Models of Immune Memory: On the Role of Cross-reactive Stimulation, Competition, and Homeostasis in Maintaining Immune Memory
2:30 pm Marcelline Kaufman
Univ. Libre de Bruxelles, Belgium
A Logical Analysis of Timing-Dependent Signaling Properties in the Immune System
3:00 pm Coffee Break EE/CS 3-176
3:20 pm Nigel Burroughs
University of Warwick
IL2 Receptor Modulation: T Cell Growth and Selection Enhancement
THURSDAY, OCTOBER 15
9:15 am Coffee Break EE/CS 3-176
9:30 am Donald MacGlashan
Johns Hopkins University
Regulation of Cell Surface FceRI Expression on Basophils
10:30 am Coffee Break EE/CS 3-176
11:00 am Richard Posner
Arizona State University
Quantifying Receptor Aggregation on the Cell Surface
2:00 pm Vincent Detours
Los Alamos National Labs
Modeling T Cell Selection
IMA MATHEMATICAL BIOLOGY SEMINAR, THURSDAY, OCTOBER 15
ROOM 409 LIND HALL
3:30 pm M.A. Herrero
University Complutense de Madrid
Mathematical Results for Some Models of Chemotaxis
6:00 pm Workshop Dinner Jewel of India Restaurant
FRIDAY, OCTOBER 16
9:15 am Coffee Break EE/CS 3-176
9:30 am Robin Callard
University College London
Cytokine Regulation of Antibody Responses
10:30 am Coffee Break EE/CS 3-176
11:00 am Rob J. De Boer
Utrecht University
Resource Competition Determines Selection of B Cell Repretoires
2:00 pm Contributed Talks
TBA
Talks will be assigned by the organizers early in the week Details will be announced as they become available.

Monday Tuesday Wednesday Thursday Friday



LIST OF CONFIRMED PARTICIPANTS

Name
Affiliation
Department
Rustom Antia Emory University Biology Dept.
Barbara Baird Cornell University Dept. of Chemistry
Jose Borghans Utrecht University Theoretical Biology
Robin Callard Institute of Child Health UCL Dept. of Immunobiology
John Cambier National Jewish Medical and Research Center  
Jeongwook Chang Seoul National University College of Natural Sciences
Carolyn R. Cho University of Toronto  
Germinal Cocho Universite Nationale Autonomas Mexico Dept. of the Institute of Physics
Rob de Boer Utrecht University Dept. of Theoretical Biology
Vincent Detours Los Alamost National Laboratories  
Stephanie Forrest University of New Mexico Dept. of Computer Science
Byron Goldstein Los Alamos National Laboratories  
Miguel A. Herrero University Complutense de Madrid Faculty of Math
William S. Hlavacek Los Alamos National Laboratories  
Marcelline Kaufman Univ. Libre de Bruxelles Service Libre de Bruxelles
Can Kesmir Technical University of Denmark Dept. of Biochemistry and Nutrition
Denise Kirschner The University of Michigan Medical Dept. of Microbiology and Immunology
Douglas Lauffenberger MIT Biomedical Engineering
Suzanne Lenhart University of Tennessee Dept. of Mathematics
Don MacGlashan Johns Hopkins University Johns Hopkins Asthma and Allergy Center 3A.38A
Ramit Mehr Princeton University Dept. of Molecular Biology
Henry Metzger NIH  
John E. Mittler Los Alamos National Laboratory  
Avidan NEUMANN Bar-Ilan University Dept. of Life Sciences
Mihaela Oprea Santa Fe Institute  
John Carl Panetta Penn State Erie, The Behrend College Dept. of Mathematics
Jerome Percus Courant Institute of Mathematical Sciences Mathematics Dept.
Alan Perelson Los Alamos National Laboratory  
Richard Posner Northern Arizona University Chemistry Dept.
Jim Samuelsson Indian Institute of Technology (IIT) Dept. of Physics
Lee Segel Weizmann Institute of Science Dept. of Applied Math & Computer Science
Phillip Seiden IBM Thomas J. Watson Research Center  
Derek Smith University of New Mexico Computer Science Dept.
Max Stafford Texas A&M, University Corpus Christi Branch Dept. of Mathematics
Jorge X. Velasco-Hernandez Cornell University Biometrics Unit
Juan J. L. Velazquaz Universidad Compulutense de Madrid  
Glenn F. Webb Vanderbilt University Dept. of Mathematics
Carla Wofsy University of New Mexico Dept. of Mathematics
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