HOME    »    PROGRAMS/ACTIVITIES    »    Annual Thematic Program
Dynamics and Control of AIDS
November 9-13, 1998



Organizers:

Denise Kirschner
University of Michigan

and

Alan Perelson
Los Alamos National Laboratory

HIV infection and AIDS are among the major unresolved health problems in this century. Mathematics can serve as an important tool in improving our understanding of the dynamics of this disease. In this workshop we will focus on modeling HIV dynamics and the interaction of HIV with the immune system. One of the hallmarks of AIDS is the decline in CD4+ T lymphocytes. After potent antiretroviral drugs are given, the concentration of HIV in blood and the lymphoid tissue declines and T cell populations recover. We will examine models of disease progression and therapy that include the kinetics of lymphocyte populations and lymphocyte trafficking in both health and disease. In addition we will consider the growth and spatial distribution of HIV during infection and treatment. Other issues we will address are viral diversity, treatment strategies and the generation of drug-resistant mutants.

Finally, the issues of disease spread at the population level will be examined. The epidemiological study of HIV has a vast literature associated with it. This workshop will not attempt to be comprehensive, but will try to present some of the key questions and results found.

Large numbers of cells and organisms, and long time scales, make differential equations the appropriate and primary tool used to study these phenomena. Delay equations, simulations and stochastic models will also play a role.



WORKSHOP SCHEDULE

All talks are in Lecture Hall EE/CS 3-180 unless otherwise noted.

Monday Tuesday Wednesday Thursday Friday

MONDAY, NOVEMBER 9
8:45 am Registration and Coffee Reception Room EE/CS 3-176
9:15 am Willard Miller, Fred Dulles and Denise Kirscher Introduction
9:30 am Alan Perelson
Los Alamos National Laboratory
Dynamic Models of HIV Infection
10:30 am Coffee Break Reception Room EE/CS 3-176
11:00 am George M. Shaw
University of Alabama at Birmingham
Evolution and Persistence of HIV-1
12:00 noon Lunch  
2:00 pm Zvia Agur
Tel Aviv University
Improving Efficacy of Anti-Viral Chemotherapy - Theory and Experimental Verification
4:00 pm IMA Tea IMA East, 400 Lind Hall
A variety of appetizers and beverages will be served.
TUESDAY, NOVEMBER 10
9:15 am Coffee Break Reception Room EE/CS 3-176
9:30 am Ashley Haase
University of Minnesota
Viral and CD4 T Cell Demographics and Dynamics in Lymphatic Tissues in HIV-1 Infection
10:30 am Coffee Break Reception Room EE/CS 3-176
11:00 am Glenn Webb
Vanderbilt University
Models of HIV-1 Disease Progression Based on Lymphocyte Re-circulation, Virus-Induced Homing, and Apoptosis of Infected CD4+ T Cells
11:15 am Lee Segel
Weizman Institute of Science
School of Mathematics Ordway Lectures
Vincent Hall 570
Some Mathematical Modeling of Allergy and Autoimmune Disease
12:00 noon Lunch  
2:00 pm Rob J. de Boer
Utrecht University
CD4 T Cell Production in Normal and Depleted Circumstances
3:00 pm Coffee Break Reception Room EE/CS 3-176
3:30 pm Nikolaos I. Stilianakis
University of Tuebingen
Department of Medical Biometry
Dynamics of Within-Host Evolution of HIV-1
WEDNESDAY, NOVEMBER 11
9:15 am Coffee Break Reception Room EE/CS 3-176
9:30 am Sally Blower
University of California
San Francisco
HIV Vaccines: Epidemic Control Strategies
10:30 am Coffee Break Reception Room EE/CS 3-176
11:00 am Carl Simon
University of Michigan
The Role of Primary Infection in the Spread of HIV and in Vaccination Strategies
12:00 noon Lunch  
2:00 pm Denise Kirschner
University of Michigan
The Role of the Thymus in Pediatric HIV-1 Infection
3:00 pm Coffee Break Reception Room EE/CS 3-176
3:30 pm Jorge Velasco-Hernandez
UAM-Iztapalapa
A Simple Vaccination Model with Multiple Steady States
5:30 pm Reception In honor of Alan Perelson's Public Lecture
7:00 pm Alan Perelson
IMA and Institute of Technology Public Lecture
Mathematics & Aids: How Mathematics Coupled with Experiment Revealed the Nature of HIV Infection
Room 100, Smith Hall
Free and Open to the Public
THURSDAY, NOVEMBER 12
9:15 am Coffee Break Reception Room EE/CS 3-176
9:30 am Steven J. Merrill
Marquette University
A Model for the Role of Infective Cofactors in AIDS
10:30 am Coffee Break Reception Room EE/CS 3-176
11:00 am Lawrence M. Wein
MIT Sloan Schol of Management
Management of Antiretroviral Therapy for HIV Infection: Analyzing When to Change Therapy
12:00 noon Lunch  
12:20 pm Lee Segel
Weizman Institute of Science
School of Mathematics Ordway Lectures
Vincent Hall 570
The Quasi-steady State Assumption and its Application in Biology
2:00 pm John Mittler
Los Alamos National Laboratory
Viral Load, HIV-1 Specific CTL, and Infected-Cell Death Rates
6:00 pm Workshop Dinner Taylor Room, 150 Lind Hall
FRIDAY, NOVEMBER 13
9:15 am Coffee Break Reception Room EE/CS 3-176
9:30 pm Avidan Neumann
Bar-Ilan University
Multi-phasic HIV Decline During HAART Explained by a CD4 Target/Helper Mathematical Model Implications for AIDS Progression, Immune Reconstitution and Vaccine Development
10:30 am Coffee Break Reception Room EE/CS 3-176
10:45 am Lisa Sattenspiel
University of Missouri
Modeling Within-group and Between-group Contact Processes: Implications for the Spread of HIV

Monday Tuesday Wednesday Thursday Friday



LIST OF CONFIRMED PARTICIPANTS

as of 11/6/98
Name
Affiliation
Department
Zvia Agur Tel Aviv University Department of Cell Research/Immunology
Sally Blower University of California-San Francisco School of Medicine
Fred Brauer University of Wisconsin-Madison Department of Mathematics
Duncan Callaway Cornell University Theoretical and Applied Mechanics
Jeongwook Chang Seoul National University College of Natural Sciences
Rob de Boer Utrecht University Department of Theoretical Biology
Fred Dulles University of Minnesota Institute for Mathematics and its Applications
Donald P. Gaver Naval Postgraduate School Operations Research
Kimber Gross University of Houston Mathematics Department
Ashley Haase University of Minnesota Department of Microbiology
Herb Hethcote University of Iowa Department of Mathematics
Sarah Holte Fred Hutchinson Cancer Research Center Department of Biostatistics
Denise Kirschner The University of Michigan Medical Department of Microbiology and Immunology
Anja Konig University of Cornell Theoretical and Applied Mechanics
James S. Koopman University of Michigan Epidemiology Department
Yoram Louzoun Hebrew University Neural Computing
Stephen J. Merrill Marquette University Department of Mathematics, Statistics, & Comp. Science
Willard Miller University of Minnesota Institute for Mathematics and its Applications
John E. Mittler Los Alamos National Laboratory  
Avidan Neumann Bar-Ilan University Department of Life Sciences
Alan Perelson Los Alamos National Laboratory  
Lisa Sattenspiel University of Missouri Department of Anthropology
Lee Segel Weizmann Institute of Science Department of Applied Mathematics & Computer Science
George M. Shaw University of Alabama at Birmingham Division of Hematology/Oncology
Carl Simon University of Michigan Mathematics Department
Max Stafford Texas A&M, University Corpus Christi Branch Department of Mathematics
Niko Stilianakis University of Tubingen Deparment of Medical Biometry
Steven H. Strogatz Cornell University Theoretical and Applied Mechanics
Jorge X. Velasco-Hernandez UAM- Iztapalapa Department of Mathematics
Glenn F. Webb Vanderbilt University Department of Mathematics
Lawrence M. Wein MIT Sloan School of Management  
Leor Weinberger Los Alamos National Laboratory  
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