Rob J. De Boer
Department of Theoretical Biology
The normal production of human naive and memory CD4 T cells is estimated from a variety of data sets. This includes data on the loss rates of chromosomal markers, recovery rates following CD4 T cell depletion, Ki67 measurements, and telomere shortening rates. These estimates are interpreted in terms of a simple mathematical model for the total body production of naive and memory CD4 T cells. The implications of these data for understanding the CD4 T cell depletion that is associated with HIV infection, and the CD4 recovery during anti-retroviral therapy, will be discussed.