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Talk Abstract
CD4 T Cell Production in Normal and Depleted Circumstances

Rob J. De Boer
Utrecht University
Department of Theoretical Biology
rdb@binf.bio.uu.nl

The normal production of human naive and memory CD4 T cells is estimated from a variety of data sets. This includes data on the loss rates of chromosomal markers, recovery rates following CD4 T cell depletion, Ki67 measurements, and telomere shortening rates. These estimates are interpreted in terms of a simple mathematical model for the total body production of naive and memory CD4 T cells. The implications of these data for understanding the CD4 T cell depletion that is associated with HIV infection, and the CD4 recovery during anti-retroviral therapy, will be discussed.

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1998-1999 Mathematics in Biology

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