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Talk Abstract
Lab-on-a-Chip Technology Including Tools for Genomics Applications

Anne R. Kopf-Sill, Ph.D.
Manager, Microfluidics & Advanced Technology
Caliper Technologies Corporation
605 Fairchild Avenue
Mountain View, CA 94043

Caliper is developing LabChipTM technology that allows manipulation of nanoliter volumes of fluids and reagents to perform a wide range of biochemical and cell-based assays. We use electrokinetic actuation to move fluids and reagents on the chip and wešve recently used the same electrical system to harness the phenomenon of Joule heating to provide rapid temperature control on LabChip devices. In this approach, feedback circuitry that monitors solution conductivity is employed to obtain inter-temperature intervals of less than a second with better than 1oC precision. Experiments are underway to use this extremely rapid temperature control system to accomplish high throughput genotyping. This presentation will cover fluid movement on LabChips, examples of biochemical assays, Joule heating for temperature control, sample accession for high-throughput experimentation, plans for high throughput genotyping, and a discussion of interesting fluid mechanics and mathematical issues in these applications.

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