Chemical and Life Science
University of Illinois-Urbana-Champaign
The discovery of Archaea as a third major domain of life, has clearly changed the way with which we understand the origins and evolution of life on earth. Archaea, although together with Bacteria are tenants of the prokaryotic world, they do share specific features with Eukarya, and they are now recognized as their closest ancestors. Their unique phylogenetic positions, and the fact that in many cases they actually bridge the gap between Eukarya and Bacteria, renders them an ideal system for genomic comparisons.
Methanococcus jannaschii was the first archaeal organisms whose genome was completely sequenced 3 years ago. In this talk I will review how the annotations of this genome have evolved along this time, through a detailed manual analysis, and which are the major problems inherent in any genome analysis related with prediction of function.1998-1999 Mathematics in Biology