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Probability and Statistics in Complex Systems: Genomics, Networks, and Financial Engineering, September 1, 2003 - June 30, 2004

Fall 2003

IMA Tutorial Week: September 15-19, 2003

Tools for Model and Data Integration in the Genome Sciences

Monday-Thursday, September 15-18, 2003

Michael A. Newton
Department of Biostatistics and Medical Informatics
University of Wisconsin-Madison
newton@stat.wisc.edu

Simon Tavaré
Program in Molecular and Computational Biology
University of Southern California
stavare@usc.edu
http://www-hto.usc.edu/people/Tavare.html

Robert Gentleman
Department of Biostatistics
Harvard University
rgentlem@jimmy.harvard.edu
http://biosun1.harvard.edu/~rgentlem/HTML/home.html

Information Integration Technologies for Complex Systems

Friday, September 19, 2003

Sallie Keller-McNulty
Group Leader for the Statistical Sciences Group
Los Alamos National Laboratory
sallie@lanl.gov
http://www.lanl.gov/orgs/d/d1/people/skeller.shtml

Alyson Gabbard Wilson
Statistical Sciences Group
Los Alamos National Laboratory
agw@lanl.gov

http://www.stat.lanl.gov/people/awilson.shtml

Schedule Participants Registration
Group Photo    Slides Format

The first four days of the tutorial, Tools for Model and Data Integration in the Genome Sciences, will provide an introduction to molecular biology and molecular technology for mathematicians and statisticians. The aim is to give a broad overview of the problems being addressed in the post-genomic era, such as array technology in human disease, mass spectrometry for protein sequencing and high throughput variation detection, regulatory networks, signal detection and comparative genomics and proteomics. The final day, on Information Integration Technologies for Complex Systems, will develop, present, and discuss a framework for the integration of experience, models and information in the highly dynamic context of contemporary scientific discovery driven by vast amounts and rapidly changing acquired information.

On the evening of September 15 there will be a lecture by Leroy Hood aimed at the general public and entitled After the Human Genome Project: Systems Biology and Predictive, Preventive and Personalized Medicine.

KICKOFF TUTORIAL SCHEDULE
Monday Tuesday
MONDAY, SEPTEMBER 15
All talks are in Lecture Hall EE/CS 3-180 unless otherwise noted.
8:30 Coffee and Registration

Reception Room EE/CS 3-176

9:15 Douglas N. Arnold, Scot Adams, and Organizers Welcome and Introduction
9:30 Simon Tavaré
University of Southern California

Intro to Molecular Biology 1

Slides:   ima1.pdf

10:20
Discussion
10:30 Coffee Break Reception Room EE/CS 3-176
11:00 Robert Gentleman
Harvard University

Basic Introduction to R and Its Philosophy

Lecture 1 Slides:   pdf

11:50
Discussion
12:00
Lunch Break
1:30 Arkady Khodursky
University of Minnesota

Microarrays: Biological, Technologicial and Analytical Issues

Slides:   pdf

2:20
Discussion
2:30 Coffee Break Reception Room EE/CS 3-176
3:00 Robert Gentleman
Harvard University

Basic Introduction to R and Its Philosophy

Lecture 2 Slides:   pdf

3:50
Discussion
4:00 Group Photo click here   Slides Format  
4:10-5-30 IMA Tea and more  
7:00-8:00 pm IMA Public Lecture:
Leroy Hood
President, Institute for Systems Biology, Seattle, Washington

After the Human Genome Project: Systems Biology and Predictive, Preventive and Personalized Medicine

Smith Hall 100, 7-8 pm

TUESDAY, SEPTEMBER 16
All talks are in Lecture Hall EE/CS 3-180 unless otherwise noted.
8:30 Coffee

Reception Room EE/CS 3-176

9:30 Charles Geyer
University of Minnesota
Introduction to Markov Chain Monte Carlo
10:20
Discussion
10:30 Coffee Break Reception Room EE/CS 3-176
11:00 Simon Tavaré
University of Southern California

Intro to Molecular Biology 2

Slides:   ima2.pdf

11:50
Discussion
12:00
Lunch Break
1:30 Robert Gentleman
Harvard University

Bioconductor, with Array Analysis

Lecture 3 Slides:   pdf

2:20
Discussion
2:30 Coffee Break Reception Room EE/CS 3-176
3:00 Simon Tavaré
University of Southern California

Genetic Variation and the HapMap Project 1

Slides:   ima3.pdf

3:50
Discussion
4:00 Walk along the Mississippi
WEDNESDAY, SEPTEMBER 17
All talks are in Lecture Hall EE/CS 3-180 unless otherwise noted.
8:30 Coffee

Reception Room EE/CS 3-176

9:30 Michael A. Newton
University of Wisconsin-Madison

Stochastic Computation Case Study 1: Dectecting Motifs, Lawrence-Liu Model

Slides:   start. pdf    loh.pdf

10:20
Discussion
10:30 Coffee Break Reception Room EE/CS 3-176
11:00 Robert Gentleman
Harvard University

Bioconductor, with Array Analysis

Slides:   pdf

11:50
Discussion
12:00
Lunch Break
1:30 Michael A. Newton
University of Wisconsin-Madison

Stochastic Computation Case Study 2: Phylogenetics, Bayesian Analysis of Trees

Slides:  ima.pdf

2:20
Discussion
2:30 Coffee Break Reception Room EE/CS 3-176
3:00 Simon Tavaré
University of Southern California

Genetic Variation and the HapMap Project 2

Slides:    ima4.pdf

3:50
Discussion
4:00
Robert Gentleman
Harvard University

Hands-on session on "R"
Lind Hall 400

THURSDAY, SEPTEMBER 18
All talks are in Lecture Hall EE/CS 3-180 unless otherwise noted.
8:30 Coffee

Reception Room EE/CS 3-176

9:30 Michael A. Newton
University of Wisconsin-Madison

Stochastic Computation Case Study 3: Cancer Genomics

Slides:   cancer.pdf

10:20
Discussion
10:30 Coffee Break Reception Room EE/CS 3-176
11:00 Robert Gentleman
Harvard University

Graphs and Networks in R

Slides:   pdf

11:50
Discussion
12:00
Lunch Break
1:30 Michael A. Newton
University of Wisconsin-Madison

Stochastic Computation Case Study 4: Gene Expression: Hierarchical Mixture Models

Slides:   arrays.pdf

2:20
Discussion
2:30 Coffee Break Reception Room EE/CS 3-176
3:00 Simon Tavaré
University of Southern California

Approximate Bayesian Computation

Slides:    ima5.pdf

3:50
Discussion
6:00 Workshop Dinner Kikugawa at Riverplace
43 Main St. SE.
Minneapolis

FRIDAY, SEPTEMBER 19
Special Mini-Workshop with Sallie Keller-McNulty and Alyson Gabbard Wilson

All talks are in Lecture Hall EE/CS 3-180 unless otherwise noted.

8:30 Coffee Reception Room EE/CS 3-176
9:00 Sallie Keller-McNulty
Los Alamos National Laboratory
Greg Wilson
Los Alamos National Laboratory

Complex Multidisciplinary R&D: Characterization of the Scientific Method and Decision Processes in this Context

Mapping Decision Spaces: Role of Ethnographic Methods

Sallie Keller-McNulty's Slides:
html    pdf    ps    ppt

Greg Wilson's Slides:
html    pdf    ps    ppts

10:00
Discussion
10:10 Coffee Break Reception Room EE/CS 3-176
10:40 Andrew Koehler
Los Alamos National Laboratory

System Representations: Graphical Models and Metaphors

Slides:  html    pdf    ps    ppt

11:40
Discussion
12:00
Lunch Break
1:30 Alyson Gabbard Wilson
Los Alamos National Laboratory

Quantification/Information Integration: Integration of Hetrogeneous Information Sources through Bayesian Methods

Slides:   pdf

2:30 Short Break  
2:40 Alyson Gabbard Wilson
Los Alamos National Laboratory

Quantification/Information Integration: Integration of Hetrogeneous Information Sources through Bayesian Methods

Slides:   pdf

3:40 Coffee Break Reception Room EE/CS 3-176
4:10 Sallie Keller-McNulty
Los Alamos National Laboratory

Assessment: Optimization and Resource (e.g., R&D) Allocation, including Evolutionary Methods

Slides:   html    pdf    ps    ppt

4:40
Discussion
4:50
Concluding Remarks by Organizers
5:00
End of Tutorial
Monday Tuesday

LIST OF CONFIRMED PARTICIPANTS
Name Department Affiliation
Scot Adams Institute for Mathematics and its Applications University of Minnesota
Soohan Ahn Department of Statistics Seoul National University (SRCCS)
Yusuf Bilgin Altundas   Schlumberger-Doll Research
Greg Anderson School of Mathematics University of Minnesota
Douglas N. Arnold Institute for Mathematics and its Applications University of Minnesota
Donald G. Aronson Institute for Mathematics and its Applications University of Minnesota
Gerard Awanou Institute for Mathematics and its Applications University of Minnesota
Karen Ball   University of Minnesota
Antar Bandyopadhyay   University of Minnesota
Maury Bramson Department of Mathematics University of Minnesota
Olga Brezhneva   University of Minnesota
Dongwei Cao Department of Computer Science University of Minnesota
Vladimir Cherkassky Department of Electrical Engineering University of Minnesota
Laura Chihara Department of Mathematics and Computer Science Carleton College
Donald Connelly Laboratory Medicine & Pathology University of Minnesota
Daya Dayananda Department of Mathematics University of St. Thomas
Ann Dewitt Department of Genomics 3M
Christian Domnisoru Software Engineering University of St. Thomas
Flora Fan "Biochemistry, Molec Biol, Biophy" University of Minnesota
Shmuel Friedland Department of Mathematics University of Illinois - Chicago
Chetan Gadgil Department of Mathematics University of Minnesota
Tim Garoni Institute for Mathematics and its Applications University of Minnesota
Robert Gentleman Department of Biostatistics Harvard School of Public Health
Charles Geyer School of Statistics University of Minnesota
Ryan Gill Department of Mathematics University of Louisville
Balaji Gopalakrishnan   University of Minnesota
Robert Gulliver School of Mathematics University of Minnesota
Chuan-Hsiang Han Ford Company University of Minnesota
Leroy E. Hood   Institute for Systems Biology
Fern Hunt Mathematical and Computational Sciences Division National Institute of Standards and Technology
Naresh Jain School of Mathematics University of Minnesota
Lili Ju   University of Minnesota
Baris M. Kazar Department of Electrical Engineering University of Minnesota
Sabera Kazi Wireless and RF Solutions Honeywell
Sallie Keller-Mcnulty Department of Statistical Sciences Los Alamos National Laboratory
Christina Kendziorski Department of Biostatistics and Medical Informatic University of Wisconsin
Mohammad Kazim Khan Department of Mathematics Kent State University
Arkady Khodursky Shannon Laboratory Biotechnology Institute University of Minnesota
Dohyun Kim Department of Statisitics Seoul National University (SRCCS)
Andrew Koehler   Los Alamos National Laboratory
Thomas G. Kurtz Department of Mathematics and Statistics University of Wisconsin
Soumendra Nath Lahiri Department of Statistics Iowa State University
Gary Lam Department of Computer Science University of Minnesota
Jeff Lande "Molecular, Cellular, Developmental Biology & Gene." University of Minnesota
Raoul LePage Department of Statistics and Probability Michigan State University
Taerim Lee Department of Information Statistics Seoul National University (SRCCS)
Qingsheng Li Department of Microbiology University of Minnesota
Daniel Maki Department of Mathematics Indiana University
Richard P. McGehee School of Mathematics University of Minnesota
Sunil Menon ES&S Labs Honeywell
Dinkar Mylaraswamy Honeywell Technology Center Honeywell
Haewon Nam   University of Minnesota
Michael Newton Department of Statistics University of Wisconsin
Amir Niknejad Department of Mathematics University of Illinois - Chicago
Sharareh Noorbaloochi Department of Electrical Engineering University of Minnesota
Lea Popovic Institute for Mathematics and its Applications University of Minnesota
Sanjive Qazi Department of Bioinformatics Parker Hughes Cancer Institute
Arvind Raghavan Department of Microbiology University of Minnesota
Shalini Raghavan Department of Genomics and Proteomics 3M
Greg Rempala Department of Mathematics University of Louisville
David Roe Department of Biology University of Minnesota
Suhas Saha Department of Economics University of Minnesota
Fadil Santosa Institute for Mathematics and its Applications University of Minnesota
Arnd Scheel Institute for Mathematics and its Applications University of Minnesota
Sashirekha Shanmugavelu Department of Computer Engineering University of Minnesota
Ruth Shaw "Department of Ecology, Evolution and Behavior" University of Minnesota
Jeffrey Silvis Space Physics Laboratory University of Minnesota
Tamon Stephen   University of Minnesota
Simon Tavare Department of Mathematics University of Southern California
Kenneth Tetrick  
Minassie Tewoldebrhan Department of Electrical and Computer Engineering University of Minnesota
Zheng Jin Tu Department of Supercomputing Institute University of Minnesota
Onder Uluyol ES&S VHM/LM Lab Honeywell
Jing Wang   University of Minnesota
Stephen J. Willson Department of Mathematics Iowa State University
Alyson Wilson Statistical Sciences Group Los Alamos National Laboratory
Greg Wilson   Los Alamos National Laboratory
Jie Xu Department of Animal Science University of Minnesota
Yuhong Yang Department of Statistics Iowa State University
Ofer Zeitouni School of Mathematics University of Minnesota
Yongqing Zhang Department of Animal Science University of Minnesota
Jun Zhao   University of Minnesota

Group Photo    Slides Format

Probability and Statistics in Complex Systems: Genomics, Networks, and Financial Engineering, September 1, 2003 - June 30, 2004