IMA Postdoc Seminar (April 8, 2008)

Speaker: Theoden Netoff (University of Minnesota)

Title: Dynamical approaches to understanding epilepsy

Abstract: Epilepsy is a dynamical disease of networks of neurons. I will talk about the different mathematical analysis tools used in our lab to help us understand the basic mechanisms of epilepsy. To understand this disease we need to bridge cellular activity to network activity. We use phase response curves to bridge changes at the cellular level to changes in behavior at the network level. To measure from hundreds of neurons simultaneously, we image slices of brain stained with calcium dyes. Processing the movies into a format that can be easily interpreted is another daunting task. We use independent component analysis and diffusion maps to process our data.