Institute for Mathematics and its Applications
114 Lind Hall
207 Church Street SE Minneapolis, MN 55455
The ultimate aim of chemistry and biology is to understand biological systems sufficiently to enable accurate, quantitative predictions
about the behaviors of the system. This includes predictions of the effects of modifications of the systems. To achieve a precise
understanding about the system it is inevitable to simulate the behavior using a computer model and compare it with experiments.
Interdisciplinary research alone can provide insights in the pursuit of this common goal. My career goal is to head an interdisciplinary
mathematical biology/chemistry group and solve complex problems in chemistry and biology using computational and
modeling approaches. I did my Ph.D. under the supervision of Prof. M. S. Gopinathan , Indian Institute of Technology Madras (IITM), India. I did my first post doctoral work with Dr. Santiago Schnell (University of Michigan Medical School)
at Indiana University School of Informatics. I am currently
a post doctoral fellow at the IMA for the year 2008-2009. I am a chemist, now conducting
reserach in solving physico-chemical problems using modelling approaches.
Modeling experimental oscillations in liquid membranes using
delay equations, J. Srividhya and M. S. Gopinathan, J. Phys. Chem. B, 2003,
107, pp 1438-1443. (pdf)
Concentration of CO2 over Melting Ice Oscillates, S. Usharani, J.
Srividhya, M. S. Gopinathan and T. Pradeep, Phys. Rev. Lett., 2004, 93(4),
Article No: 048304, pp 1-4. (pdf)
A simple time delay model for eukaryotic cell cycle, J. Srividhya
and M. S. Gopinathan, J. theor. Biol., 2006, 214(3), pp 617-627. (pdf)
Why substrate disappearance in enzyme digestion follows apparent
first-order kinetics, J. Srividhya and Santiago Schnell, Comp. Biol. Chem.,
2006, 30, pp 209-214. (pdf)
Reconstructing biochemical pathways from time series
data. J. Srividhya, Santiago Schnell, Edmund J Crampin and Patrick E McSharry, 2007, Proteomics, 7, 828 - 838. (invited paper) . (pdf)
Effect of time delay in a model of
phosphorylation-dephosphorylation network. J. Srividhya, M. S. Gopinathan and
Santiago Schnell, Biophysical chemistry, 2007, 125, pp 286-297. (pdf)
Enzyme catalyzed reactions: from experiments to mechanism reconstruction. J. Srividhya, Marcio D. A. Maurao, Edmund J. Crampin, Santiago Schnell, Comp. Biol.(accepted)
A length induced positive feedback in open signal transduction cascades is revealed. J. Srividhya, Yongfeng Li and Joe Pomerening, PLoS Comp. Biol. (under revision)
Goldbeter-Koshland model for open signaling cascades: A mathematical study. Yongfeng Li and J. Srividhya, J. Math. Biol. (submitted)
Marcio D. A. Maurao and J. Srividhya, Reverse engineering in biology: Past, present and future.(To be submitted)
1. A preliminary version of MIKANA is here. We are working on building a more concise version for general use. You can also find an other software for
enzyme kinetics parameter estimation developed by (our) Dr. Schnell's group.
2. You can find a simulable version of my cell cycle model here.
Cell cycle model simulation
1. Our JTB paper was one of the 25 top downloaded article. Check it here!
2. Our Proteomics article was selected as in the Issue article and Dr. Schnell was interviewed. You can download the podcast titled "March, 2007"