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Change-Plane Analysis for Subgroup Detection and Sample Size Calculation

Thursday, September 14, 2017 - 4:00pm - 4:30pm
Keller 3-180
Rui Song (North Carolina State University)
We propose a systematic method for testing and identifying a subgroup with an enhanced treatment eect. We adopts a change-plane technique to first test the existence of a subgroup, and then identify the subgroup if the null hypothesis on non-existence of such a subgroup is rejected. A semiparametric model is considered for the response with an unspecied baseline function and an interaction between a subgroup indicator and treatment. A doubly-robust test statistic is constructed based on this model, and asymptotic distributions of the test statistic under both null and local alternative hypotheses are derived. Moreover, a sample size calculation method for subgroup detection is developed based on the proposed statistic. The finite sample performance of the proposed test is evaluated via simulations. Finally, the proposed methods for subgroup identification and sample size calculation are applied to a data set from an AIDS study.