Multiscale Modeling of Axonal Cytoskeleton Dynamics in Diseases
Wednesday, May 30, 2018 - 2:40pm - 3:30pm
The shape and function of an axon is dependent on its cytoskeleton, including microtubules, neurofilaments and actin. Neurofilaments accumulate abnormally in axons in many neurological disorders. An early event of such accumulation is a striking radial segregation of microtubules and neurofilaments. I will present a stochastic multiscale model that explained these phenomena and generated testable predictions, new experiments in Dr. Anthony Brown's lab that confirmed the model predictions, and a continuum PDE model extracted from the stochastic model. The PDE model is analytically more tractable and computationally more efficient.