Dynamics of DNA supercoiling, knotting, and compaction

Tuesday, June 25, 2019 - 10:15am - 11:15am
Keller 3-180
David Swigon (University of Pittsburgh)
Study of the dynamics of elastic rods submerged in a viscous incompressible fluid has been conducted in order to gain understanding of the dynamical behavior of DNA molecules. The governing equations of the system are solved numerically using the generalized immersed boundary method. The equations of motion of the rod include the fluid–structure interaction, rod elasticity and a combination of two interactions that prevent self-contact, namely the electrostatic interaction and hard-core repulsion. Presented will be results on the effects of electrostatics, steric repulsion, and thermal fluctuations on supercoiling and knotting dynamics.