Folding pathways for knotted proteins

Wednesday, June 26, 2019 - 3:00pm - 4:00pm
Keller 3-180
Helen Wong (Claremont McKenna College)
A small but significant portion of proteins contain knotting, but very little is known about how those proteins fold into their knotted native states. In this talk, we introduce a new theoretical folding pathway for knotted proteins that is based on recent computational and experimental evidence. By analyzing fingerprint data from the crystal structures of knotted proteins, we identify pathways from the new theory that are likely to describe folding for certain families of knotted proteins. This is joint work with Erica Flapan and Adam He.