Mathematical modeling

Thursday, March 6, 2008 - 2:50pm - 3:30pm
H. Steven Wiley (Pacific Northwest National Laboratories)
The epidermal growth factor receptor (EGFR) is a central signal transduction pathway in epithelial cells and regulates diverse biological responses such as proliferation, migration and differentiation. Ligands for the EGFR, such as amphiregulin and TGFa are synthesized as membrane-anchored precursors and released by regulated proteolysis, leading to autocrine signaling. Ligand shedding is controlled by a number of different hormones and is responsible for EGFR “transactivation” or crosstalk.


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